Periorbital melanosis and its possible association with insulin resistance and vitamin D deficiency: A pilot case-control study.
J Int Med Res
; 52(8): 3000605241270648, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-39161263
ABSTRACT
OBJECTIVE:
To investigate the possible association of periorbital melanosis (POM) with insulin resistance (IR) and vitamin D serum levels.METHODS:
In this pilot, case-control study, we included 100 adult patients with POM and 100 age- and sex-matched healthy control subjects. Vitamin D levels and IR indices (i.e., homeostatic model assessment-insulin resistance [HOMA-IR], triglycerides/high-density lipoprotein cholesterol (TG/HDL-c) ratio, adiponectin/leptin (A/L) ratio) were compared between cases and controls.RESULTS:
Compared with controls, POM cases had significantly higher values of HOMA-IR and TG/HDL-c ratio, and significantly lower values of A/L and vitamin D. HOMA-IR and TG/HDL-c ratio were statistically significantly positively correlated with POM severity while Vitamin D and A/L ratio were statistically significantly negatively correlated.CONCLUSION:
POM was associated with indices of IR and vitamin D deficiency. However, the exact causal link among POM, IR, and vitamin D needs to be established. However, the results of this pilot study suggest that POM may have potential as a cutaneous non-invasive marker of these metabolic disorders which would assist in detecting and treating them at an early stage.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vitamin D
/
Vitamin D Deficiency
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Insulin Resistance
/
Adiponectin
/
Melanosis
Limits:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
J Int Med Res
Year:
2024
Document type:
Article
Affiliation country:
Egypt
Country of publication:
United kingdom