Lymph Node Metastasis in Gastrointestinal Carcinomas: A View from a Proteomics Perspective.
Curr Oncol
; 31(8): 4455-4475, 2024 Aug 02.
Article
in En
| MEDLINE
| ID: mdl-39195316
ABSTRACT
Lymph node metastasis (LNM) is one of the major prognostic factors in human gastrointestinal carcinomas (GICs). The lymph node-positive patients have poorer survival than node-negative patients. LNM is directly associated with the recurrence and poor survival of patients with GICs. The early detection of LNM in patients and designing effective therapies to suppress LNM may significantly impact the survival of these patients. The rapid progress made in proteomic technologies could be successfully applied to identify molecular targets for cancers at high-throughput levels. LC-MS/MS analysis enables the identification of proteins involved in LN metastasis, which can be utilized for diagnostic and therapeutic applications. This review summarizes the studies on LN metastasis in GICs using proteomic approaches to date.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Proteomics
/
Gastrointestinal Neoplasms
/
Lymphatic Metastasis
Limits:
Humans
Language:
En
Journal:
Curr Oncol
Year:
2024
Document type:
Article
Affiliation country:
India
Country of publication:
Switzerland