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Decellularized Antler Cancellous Bone Matrix Material Can Serve as Potential Bone Tissue Scaffold.
Wang, Yusu; Zong, Ying; Chen, Weijia; Diao, Naichao; Zhao, Quanmin; Li, Chunyi; Jia, Boyin; Zhang, Miao; Li, Jianming; Zhao, Yan; Du, Rui; He, Zhongmei.
Affiliation
  • Wang Y; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
  • Zong Y; Institute of Antler Science and Product Technology, Changchun Sci-Tech University, Changchun 130112, China.
  • Chen W; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
  • Diao N; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
  • Zhao Q; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
  • Li C; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
  • Jia B; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
  • Zhang M; Institute of Antler Science and Product Technology, Changchun Sci-Tech University, Changchun 130112, China.
  • Li J; College of Animal Medicine, College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China.
  • Zhao Y; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
  • Du R; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
  • He Z; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Biomolecules ; 14(8)2024 Jul 25.
Article in En | MEDLINE | ID: mdl-39199295
ABSTRACT
Due to the limited supply of autologous bone grafts, there is a need to develop more bone matrix materials to repair bone defects. Xenograft bone is expected to be used for clinical treatment due to its exact structural similarity to natural bone and its high biocompatibility. In this study, decellularized antler cancellous bone matrix (DACB) was first prepared, and then the extent of decellularization of DACB was verified by histological staining, which demonstrated that it retained the extracellular matrix (ECM). The bioactivity of DACB was assessed using C3H10T1/2 cells, revealing that DACB enhanced cell proliferation and facilitated cell adhesion and osteogenic differentiation. When evaluated by implanting DACB into nude mice, there were no signs of necrosis or inflammation in the epidermal tissues. The bone repair effect of DACB was verified in vivo using sika deer during the antler growth period as an animal model, and the molecular mechanisms of bone repair were further evaluated by transcriptomic analysis of the regenerated tissues. Our findings suggest that the low immunogenicity of DACB enhances the production of bone extracellular matrix components, leading to effective osseointegration between bone and DACB. This study provides a new reference for solving bone defects.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antlers / Osteogenesis / Deer / Tissue Scaffolds / Cancellous Bone / Mice, Nude Limits: Animals Language: En Journal: Biomolecules Year: 2024 Document type: Article Affiliation country: China Country of publication: Switzerland

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antlers / Osteogenesis / Deer / Tissue Scaffolds / Cancellous Bone / Mice, Nude Limits: Animals Language: En Journal: Biomolecules Year: 2024 Document type: Article Affiliation country: China Country of publication: Switzerland