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The Emergence and Impact of the M1UK Lineage on Invasive Group A Streptococcus Disease in Aotearoa New Zealand.
Vesty, Anna; Ren, Xiaoyun; Sharma, Prachi; Lorenz, Natalie; Proft, Thomas; Hardaker, Allan; Straub, Christina; Morgan, Julie; Tiong, Audrey; Anderson, Anneka; Webb, Rachel H; Bennett, Julie; Carter, Philip E; Moreland, Nicole J.
Affiliation
  • Vesty A; The Institute of Environment Science and Research, Porirua, New Zealand.
  • Ren X; School of Medical Sciences, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
  • Sharma P; The Institute of Environment Science and Research, Porirua, New Zealand.
  • Lorenz N; School of Medical Sciences, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
  • Proft T; School of Medical Sciences, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
  • Hardaker A; School of Medical Sciences, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
  • Straub C; The Institute of Environment Science and Research, Porirua, New Zealand.
  • Morgan J; The Institute of Environment Science and Research, Porirua, New Zealand.
  • Tiong A; The Institute of Environment Science and Research, Porirua, New Zealand.
  • Anderson A; The Institute of Environment Science and Research, Porirua, New Zealand.
  • Webb RH; Te Kupenga Hauora Maori, The University of Auckland, Auckland, New Zealand.
  • Bennett J; Department of Paediatrics, Child and Youth Health, The University of Auckland, Auckland, New Zealand.
  • Carter PE; School of Medical Sciences, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
  • Moreland NJ; Department of Public Health, University of Otago, Wellington, New Zealand.
Open Forum Infect Dis ; 11(8): ofae457, 2024 Aug.
Article in En | MEDLINE | ID: mdl-39205925
ABSTRACT
M1UK is associated with current surges in invasive infection globally, partly due to increased production of superantigen streptococcal pyrogenic exotoxin A. We show that M1UK is now the dominant invasive emm1 lineage in Aotearoa New Zealand and is genomically related to community infections, suggesting that measures that effectively prevent group A Streptococcus pharyngitis in children could reduce invasive disease.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Open Forum Infect Dis Year: 2024 Document type: Article Affiliation country: New Zealand
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Open Forum Infect Dis Year: 2024 Document type: Article Affiliation country: New Zealand