A case of NONO::TFE3 cutaneous epithelioid and spindle cell tumor with local recurrence after complete excision.
J Cutan Pathol
; 2024 Aug 29.
Article
in En
| MEDLINE
| ID: mdl-39206664
ABSTRACT
Mesenchymal tumors may display morphologic and immunohistochemical overlap with melanocytic tumors, presenting a pitfall for misdiagnosis. We report a 62-year-old woman who presented with a recurrent dermal and subcutaneous tumor over the Achilles tendon 15 years following complete excision. Both the primary and the recurrent tumors were characterized by nests and sheets of epithelioid and spindle cells with eosinophilic cytoplasm and uniform ovoid nuclei. The tumor was positive for S100, SOX10, HMB45, cathepsin K, and p63 (weak), while negative for Melan-A, MiTF, smooth muscle actin, and desmin. Gene fusion analysis of the recurrent tumor revealed a NONOTFE3 fusion which has been recently reported in two similar cutaneous cases. Our case highlights the potential of a NONOTFE3 cutaneous epithelioid and spindle cell tumor to recur after a prolonged disease-free interval without evidence of high-grade transformation or distant metastasis. Our findings support its classification as a cutaneous mesenchymal neoplasm of intermediate malignancy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Cutan Pathol
Year:
2024
Document type:
Article
Affiliation country:
United States
Country of publication:
United States