Can infliximab serve as a new therapy for neuropsychiatric symptoms?
Naunyn Schmiedebergs Arch Pharmacol
; 2024 Sep 03.
Article
in En
| MEDLINE
| ID: mdl-39225829
ABSTRACT
Neuropsychiatric disorders present a global challenge to public health. Mechanisms associated with neuropsychiatric disorders etiology include apoptosis, oxidative stress, and neuroinflammation. Tumor necrosis factor alpha, an inflammatory cytokine, mediates pathophysiology of neuropsychiatric disorders. Therefore, its inhibition by infliximab might afford a valuable target for intervention. Infliximab is commonly used to treat inflammatory diseases, including ulcerative colitis, Crohn's disease, and rheumatoid arthritis. Recently, it has been shown that infliximab improves cognitive dysfunction, depression, anxiety, and life quality. Here, we review contemporary knowledge supporting the need to further characterize infliximab as a potential treatment for neuropsychiatric disorders.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Naunyn Schmiedebergs Arch Pharmacol
Year:
2024
Document type:
Article
Affiliation country:
Iran