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Lack of classical astroblastoma features in pediatric MN1::BEND2-fused brain tumors.
Chapman, Nicholas; Iqbal, Mohammed; Walker, Adam D; Hawes, Debra; Davidson, Tom Belle; Robison, Nathan; Tamrazi, Benita; Ji, Jianling; Krieger, Mark D; Cotter, Jennifer A.
Affiliation
  • Chapman N; Department of Surgery and Division of Neurosurgery, Children's Hospital Los Angeles, Los Angeles, California, USA.
  • Iqbal M; Department of Neurosurgery, University of Texas, Dell Medical School, Austin, Texas, USA.
  • Walker AD; Department of Pathology & Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA.
  • Hawes D; Department of Pathology & Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA.
  • Davidson TB; Keck School of Medicine, University of Southern California, Los Angeles, California, United States.
  • Robison N; Keck School of Medicine, University of Southern California, Los Angeles, California, United States.
  • Tamrazi B; Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, California, USA.
  • Ji J; Keck School of Medicine, University of Southern California, Los Angeles, California, United States.
  • Krieger MD; Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, California, USA.
  • Cotter JA; Keck School of Medicine, University of Southern California, Los Angeles, California, United States.
Brain Pathol ; : e13297, 2024 Sep 05.
Article in En | MEDLINE | ID: mdl-39237118
ABSTRACT
Three distinct MN1BEND2 fusion-positive tumors in pediatric patients. (A) Clinical course for each patient was variable in part due to differences in initial diagnosis. Each patient responded favorably to gross total resection and is stable at last follow-up. (B) Histologic diversity, lack of prominent classical astroblastoma features, and variable immunoexpression of key markers makes microscopic diagnosis challenging.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Brain Pathol Journal subject: CEREBRO / PATOLOGIA Year: 2024 Document type: Article Affiliation country: United States Country of publication: Switzerland
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Brain Pathol Journal subject: CEREBRO / PATOLOGIA Year: 2024 Document type: Article Affiliation country: United States Country of publication: Switzerland