The bioenergetics of traumatic brain injury and its long-term impact for brain plasticity and function.
Pharmacol Res
; 208: 107389, 2024 Oct.
Article
in En
| MEDLINE
| ID: mdl-39243913
ABSTRACT
Mitochondria provide the energy to keep cells alive and functioning and they have the capacity to influence highly complex molecular events. Mitochondria are essential to maintain cellular energy homeostasis that determines the course of neurological disorders, including traumatic brain injury (TBI). Various aspects of mitochondria metabolism such as autophagy can have long-term consequences for brain function and plasticity. In turn, mitochondria bioenergetics can impinge on molecular events associated with epigenetic modifications of DNA, which can extend cellular memory for a long time. Mitochondrial dysfunction leads to pathological manifestations such as oxidative stress, inflammation, and calcium imbalance that threaten brain plasticity and function. Hence, targeting mitochondrial function may have great potential to lessen the outcomes of TBI.
Key words
7,8-DHF (PubChem CID: 3818303-8); Bumetanide (PubChem CID: 2471); Cyclosporin (PubChem CID: 5284373); Dexmedetomidine (PubChem CID: 5311068); Epigenetic; Etifoxine (PubChem CID: 135413553); Hunanin (PubChem CID: 16135997); Inflammation; Kaempferol (PubChem CID: 5280863); MCC950 (PubChem CID: 9910393); Melatonin (PubChem CID: 896); Minocycline (PubChem CID: 54675783); Mitochondrial dynamics; Mitophagy; Pramipexole (PubChem CID: 119570); Quercetin (PubChem CID: 5280343); R13 (PubChem CID: 90117609); Rapamycin (PubChem CID: 5284616); Resolvin D1 (PubChem CID: 44251266); Ru360 (PubChem CID: 85392867); SS-31 (PubChem CID: 11764719); Salubrinal (PubChem CID: 5717801); Sevoflurane (PubChem CID: 5206); Traumatic brain injury; Triiodothyronine (PubChem CID: 5920); oxidative stress
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Energy Metabolism
/
Brain Injuries, Traumatic
/
Mitochondria
/
Neuronal Plasticity
Limits:
Animals
/
Humans
Language:
En
Journal:
Pharmacol Res
Journal subject:
FARMACOLOGIA
Year:
2024
Document type:
Article
Country of publication:
Netherlands