Systematic review and recommendations for re-irradiation for intraprostatic radiorecurrent prostate cancer after definitive radiation therapy.
World J Urol
; 42(1): 520, 2024 Sep 12.
Article
in En
| MEDLINE
| ID: mdl-39264453
ABSTRACT
PURPOSE:
Intraprostatic recurrence (IRR) of prostate cancer after radiation therapy is increasingly identified. Our objective was to review the literature to determine the optimal workup for identifying IRR, the management options, and practical considerations for the delivery of re-irradiation as salvage local therapy.METHODS:
We performed a systematic review of available publications and ongoing studies on the topics of IRR, with a focus on salvage re-irradiation.RESULTS:
Work up of biochemically recurrent prostate cancer includes PSMA PET/CT and multiparametric MRI, followed by biopsy to confirm IRR. Management options include continued surveillance, palliative hormonal therapy, and salvage local therapy. Salvage local therapy can be delivered using re-irradiation with low dose rate brachytherapy, high dose rate (HDR) brachytherapy, and stereotactic body radiotherapy (SBRT), as well as non-radiation modalities, such as cryotherapy, high-intensity focused ultrasound, irreversible electroporation and radical prostatectomy. Data demonstrate that HDR brachytherapy and SBRT have similar efficacy compared to the other salvage local therapy modalities, while having more favorable side effect profiles. Recommendations for radiation therapy planning and delivery using HDR and SBRT based on the available literature are discussed.CONCLUSION:
Salvage re-irradiation is safe and effective and should be considered in patients with IRR.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prostatic Neoplasms
/
Salvage Therapy
/
Re-Irradiation
/
Neoplasm Recurrence, Local
Limits:
Humans
/
Male
Language:
En
Journal:
World J Urol
Year:
2024
Document type:
Article
Affiliation country:
United States
Country of publication:
Germany