An Inhalable Nanoshield for Effective Prevention of Influenza Virus Infections.
ACS Nano
; 18(40): 27327-27339, 2024 Oct 08.
Article
in En
| MEDLINE
| ID: mdl-39315858
ABSTRACT
Influenza virus (IV) infection currently poses a serious and continuing threat to the global public health. Developing effective prevention strategies is important to defend against infection and spread of IV. Here, we developed a triple-protective nanoshield against IV infection in the lungs, formed by self-assembling DSPE-PEG amphiphilic polymers encapsulating the flu-preventive antiviral drug Arbidol internally. The preventive effect of the nanoshield against virus infection includes increasing the viscosity in the surrounding environment to physically defend against viral entry, forming a hydrated layer to block the interaction between viruses and cells, and inhibiting virus replication. Our finding suggested that a single inhalation of the nanoshield provides effective protection against IV infection for at least 8 h. Thus, this nanoshield may be a potential pandemic protection agent against IV, especially in viral environments, where no prophylactic or therapeutic measures are available.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antiviral Agents
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
ACS Nano
Year:
2024
Document type:
Article
Country of publication:
United States