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Pretransplant MRD detection of fusion transcripts is strongly prognostic in KMT2A-rearranged acute myeloid leukemia.
Loo, Sun; Potter, Nicola; Ivey, Adam; O'Nions, Jenny; Moon, Roderick; Jovanovic, Jelena; Fong, Chun Yew; Anstee, Natasha S; Tiong, Ing S; Othman, Jad; Chua, Chong Chyn; Renshaw, Hannah; Baker, Robert; Fleming, Shaun; Russell, Nigel H; Ritchie, David; Bajel, Ashish; Hou, Hsin-An; Dillon, Richard James; Wei, Andrew H.
Affiliation
  • Loo S; Peter MacCallum Cancer Centre and Royal Melbourne Hospital, 3052, Australia.
  • Potter N; King's College, London, United Kingdom.
  • Ivey A; The Alfred Hospital, Melbourne, Australia.
  • O'Nions J; University College London Hospitals NHS Foundation Trust, London, United Kingdom.
  • Moon R; Alfred Health, Melbourne, Australia.
  • Jovanovic J; King's College London, London, United Kingdom.
  • Fong CY; Austin Health, Heidelberg, Australia.
  • Anstee NS; Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
  • Tiong IS; Peter MacCallum Cancer Centre, Melbourne, Australia.
  • Othman J; Kings College London, London, United Kingdom.
  • Chua CC; 2. The Walter and Eliza Hall Institute of Medical Research, Australia.
  • Renshaw H; UCLH, London, United Kingdom.
  • Baker R; Health Services Laboratories, London, United Kingdom.
  • Fleming S; Alfred Health, Ashwood, Australia.
  • Russell NH; Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
  • Ritchie D; Peter MacCallum Cancer Centre and Royal Melboure Hospital, Melbourne, Australia.
  • Bajel A; Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, Australia.
  • Hou HA; National Taiwan University Hospital, Taipei, Taiwan.
  • Dillon RJ; King's College, London, London, United Kingdom.
  • Wei AH; Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Australia.
Blood ; 2024 Sep 24.
Article in En | MEDLINE | ID: mdl-39316646
ABSTRACT
Pre-transplant detection of KMT2Ar MRD ≥0.001% by quantitative PCR was associated with significantly inferior post-transplant survival (2-year RFS 17% vs 59%; p=0.001) and increased cumulative incidence of relapse (2-year CIR 75% vs 25%, p=0.0004).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Blood Year: 2024 Document type: Article Affiliation country: Australia Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Blood Year: 2024 Document type: Article Affiliation country: Australia Country of publication: United States