A Comprehensive Review on Computational Analysis, Research Advances, and Major Findings on Abdominal Aortic Aneurysms for the Years 2021 to 2023.

ABSTRACT

BACKGROUND: Abdominal aortic aneurysm (AAA) is a pathological condition characterized by the dilation of the lower part of the aorta, where significant hemodynamic forces are present. The prevalence and high mortality risk associated with AAA remain major concerns within the scientific community. There is a critical need for extensive research to understand the underlying mechanisms, pathophysiological characteristics, and effective detection methods for abdominal aortic abnormalities. Additionally, it is imperative to develop and refine both medical and surgical management strategies. This review aims to indicate the role of computational analysis in the comprehension and management of AAAs and covers recent research studies regarding the computational analysis approach conducted between 2021 and 2023. Computational analysis methods have emerged as sophisticated and noninvasive approaches, providing detailed insights into the complex dynamics of AAA and enhancing our ability to study and manage this condition effectively. METHODS: Computational analysis relies on fluid mechanics principles applied to arterial flow, using the Navier-Stokes equations to model blood flow dynamics. Key hemodynamic indicators relevant to AAAs include Time-Average Wall Shear Stress, Oscillatory Shear Index, Endothelial Cell Activation Potential, and Relative Residence Time. The primary methods employed for simulating the abdominal aorta and studying its biomechanical environment are computational fluid dynamics and Finite Element Methods. This review article encompasses a thorough examination of recent literature, focusing on studies conducted between 2021 and 2023. RESULTS: The latest studies have elucidated crucial insights into the blood flow characteristics and geometric attributes of AAAs. Notably, blood flow patterns within AAAs are associated with increased rupture risk, along with elevated intraluminal thrombus volume and specific calcification thresholds. Asymmetric AAAs exhibit heightened risks of rupture and thrombus formation due to low and oscillating wall shear stresses. Moreover, larger aneurysms demonstrate increased wall stress, pressure, and energy loss. Advanced modeling techniques have augmented predictive capabilities concerning growth rates and surgical thresholds. Additionally, the influence of material properties and thrombus volume on wall stress levels is noteworthy, while inlet velocity profiles significantly modulate blood flow dynamics within AAAs. CONCLUSIONS: This review highlights the potential utility of computational modeling. However, the clinical applicability of computational modeling has been limited by methodological variability despite the ongoing accumulation of evidence supporting the prognostic significance of biomechanical and hemodynamic indices in this field. The establishment of standardized reporting is critical for clinical implementation.