Serum levels of procaine in human after peri-oral injections.
Pharmazie
; 40(2): 118-20, 1985 Feb.
Article
in En
| MEDLINE
| ID: mdl-4001146
ABSTRACT
Doses of procaine for dental purposes have been assessed previously as a result of studies of circulating blood levels of procaine after injection of the drug at body sites other than the mouth. This paper reports results of a study of circulating procaine levels in ten healthy volunteers who received 1.8 ml injections of 2% procaine hydrochloride at a defined peri-oral site. General dental practice conditions were simulated as closely as possible. In addition, procaine pharmacokinetics following peri-oral administration were studied. The serum concentration-time data were found to obey the one-compartment open model adequately with first-order absorption and elimination rates.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Procaine
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
Pharmazie
Journal subject:
FARMACIA
Year:
1985
Document type:
Article