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Nosocomial outbreak of Candida parapsilosis fungemia related to intravenous infusions.
Arch Intern Med ; 137(12): 1686-9, 1977 Dec.
Article in En | MEDLINE | ID: mdl-412474
ABSTRACT
Candida parapsilosis is rarely isolated from blood cultures. Our hospital surveillance detected an increased rate of isolation of C parapsilosis during a four month period. Fourteen postoperative patients receiving intravenous (IV) hyperalimentation and eight burn patients receiving IV albumin were involved. Hectic fever, the major clinical manifestation, was seen in 61% of cases. Therapy in the postoperative patients consisted merely of discontinuing IV catheters and hyperalimentation, while amphotericin B was needed in five of eight burn patients to control persistent fungemia. Epidemiologic analysis identified a source of the organism in the IV-additive preparation room where C parapsilosis was found contaminating a vacuum system. Organisms apparently refluxed into IV bottles when aliquots were removed to accommodate additives. Of 103 patients who received fluids prepared with the contaminated system, 21% became infected with C parapsilosis. Infection surveillance was instrumental in detection and control of the outbreak. Routine guideline should be established to insure the sterility of IV fluids containing additives.
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Collection: 01-internacional Database: MEDLINE Main subject: Candidiasis / Cross Infection / Disease Outbreaks / Parenteral Nutrition, Total / Parenteral Nutrition / Sepsis Type of study: Guideline Limits: Adult / Aged / Humans / Middle aged Country/Region as subject: America do norte Language: En Journal: Arch Intern Med Year: 1977 Document type: Article
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Collection: 01-internacional Database: MEDLINE Main subject: Candidiasis / Cross Infection / Disease Outbreaks / Parenteral Nutrition, Total / Parenteral Nutrition / Sepsis Type of study: Guideline Limits: Adult / Aged / Humans / Middle aged Country/Region as subject: America do norte Language: En Journal: Arch Intern Med Year: 1977 Document type: Article