Dialkyl esters of methotrexate and 3',5'-dichloromethotrexate: synthesis and interaction with aldehyde oxidase and dihydrofolate reductase.

Johns, D G; Farquhar, D; Wolpert, M K; Chabner, B A; Loo, T L

Johns, D G; Farquhar, D; Wolpert, M K; Chabner, B A; Loo, T L.

Drug Metab Dispos ; 1(3): 580-9, 1973.

Article in En | MEDLINE | ID: mdl-4149453

Subject(s)

Aldehyde Oxidoreductases/metabolism; Methotrexate/metabolism; Tetrahydrofolate Dehydrogenase/metabolism; Animals; Cells, Cultured; Chemical Phenomena; Chemistry; Chlorine; Esters/metabolism; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Leukemia L1210/enzymology; Liver/enzymology; Oxidation-Reduction; Rabbits; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet

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Collection: 01-internacional Database: MEDLINE Main subject: Tetrahydrofolate Dehydrogenase / Methotrexate / Aldehyde Oxidoreductases Limits: Animals Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 1973 Document type: Article

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