[Interactions between a progestational derivative (norethisterone acetate) and ethinyl estradiol on urinary elimination of neurophysin, ocytocin, and vasopressin and on the blood level of neurophysin I and II in normal human beings]. / Interactions entre un dérivé progestatif (acétate de noréthistérone) et l'éthinyl oestradiol sur l'élimination urinaire de neurophysine, d'ocytocine et de vasopressine immunoréactives et sur le taux de neurophysine sérique I et II chez l'homme normal
C R Seances Soc Biol Fil
; 167(11): 1668-72, 1973.
Article
in Fr
| MEDLINE
| ID: mdl-4609573
ABSTRACT
PIP Neurophysin 1 (a peptide associated with antidiuretic homone, ADH), ADH, and oxytocin were measured in serum or urine of 3 men who took 10 mcg ethinyl estradiol with 5 mg norethisterone acetate twice daily for 6 days and in 3 who took the estrogen only. Neurophysin in plasma was determined by radioimmunoassy, and individually by starch gel electrophoresis, extraction, and assay. Total urine neurophysin was measured by radioimmunoassy. ADH and oxytocin were quantitated by column chromatography and radioimmunoassy. With both steroids, there was no change in neurophysin, ADH, or oxytocin. Ethinyl estradiol alone increased urinary neurophysin from 112.3 to 595 ng/hour (n.s.), oxytocin from 41-132 ng/hour (p less than .005), and ADH from 9.7-57.2 ng/hour (p less than .01). As in pregnant women compared to normal women, estrogen treatment stimulated plasma neurophysin 1 more than neurophysin 2 in these subjects. These results confirm those found in rats.^ieng
Key words
Biology; Clinical Research; Contraception; Contraceptive Agents, Estrogen--side effects; Contraceptive Agents, Female--side effects; Contraceptive Agents, Progestin--side effects; Contraceptive Agents--side effects; Endocrine System; Ethinyl Estradiol--side effects; Family Planning; Hormones; Norethindrone Acetate--side effects; Norethindrone--side effects; Oxytocin--analysis; Physiology; Pituitary Hormones--analysis; Pregnancy; Reproduction; Research Methodology
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Neurophysins
/
Oxytocin
/
Vasopressins
/
Ethinyl Estradiol
/
Hypothalamus
/
Norethindrone
Type of study:
Clinical_trials
Limits:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
Language:
Fr
Journal:
C R Seances Soc Biol Fil
Year:
1973
Document type:
Article