The effect of H1 and H2 histamine antagonists on symptomatic dermographism.
Br J Dermatol
; 101(1): 57-61, 1979 Jul.
Article
in En
| MEDLINE
| ID: mdl-475988
ABSTRACT
In ten patients suffering from symptomatic dermographism the combined administration of chlorpheniramine + cimetidine produced a greater reduction in the weal and flare response provoked by a standardized scratch than the administration of chlorpheniramine alone. There was a statistically significant improvement in the overall assessment of the patient's skin condition with the combined administration of chlorpheniramine + cimetidine. Chlorpheniramine given alone produced no significant benefit whilst cimetidine alone produced a marked exacerbation in itching in nearly half the patients who initially entered the study and was sufficient to require withdrawal.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Urticaria
/
Chlorpheniramine
/
Cimetidine
/
Guanidines
Type of study:
Clinical_trials
/
Diagnostic_studies
/
Evaluation_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Br J Dermatol
Year:
1979
Document type:
Article