Potentiation of neuromuscular weakness in infant botulism by aminoglycosides.
J Pediatr
; 95(6): 1065-70, 1979 Dec.
Article
in En
| MEDLINE
| ID: mdl-501488
ABSTRACT
A retrospective study of ten patients with infant botulism who received gentamicin or kanamycin suggests that aminoglycoside antibiotics potentiate muscular weakness and precipitate respiratory failure as late as 27 days after onset of the disease. Although it is difficult to separate progression of the disease from the effects of antibiotics, the rapidity of deterioration following aminoglycoside treatment and the rapidity of recovery following cessation of aminoglycoside therapy is highly suggestive. A review of five patients who received only penicillin or a semisynthetic derivative of penicillin did not reveal any temporal deterioration with onset of penicillin therapy or improvement with cessation of penicillin therapy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Botulism
/
Gentamicins
/
Kanamycin
/
Muscle Hypotonia
Type of study:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Humans
/
Infant
/
Male
/
Newborn
Language:
En
Journal:
J Pediatr
Year:
1979
Document type:
Article