Correlations of parotid saliva and plasma lidocaine concentrations in rats.
J Pharm Sci
; 68(9): 1192-3, 1979 Sep.
Article
in En
| MEDLINE
| ID: mdl-501552
ABSTRACT
The concentration ratios of parotid saliva to plasma lidocaine were determined in rats after a single dose (10 mg of lidocaine/kg) and constant infusion (60 micrograms of lidocaine/kg/min). Parotid saliva and plasma samples were obtained at 10, 20, and 30 min after single-dose lidocaine administration and at 70, 80, and 90 min after the initiation of a lidocaine infusion. The saliva/plasma concentration ratios for lidocaine after single-dose administration decreased from 1.13 +/- 0.03 at 10 min to 0.51 +/- 0.06 at 30 min, whereas the ratios determined during the lidocaine infusion remained constant (0.43 +/- 0.03, 0.45 +/- 0.03, and 0.43 +/- 0.04) over the time period tested. The variable saliva/plasma concentration ratios obtained after single-dose administration may be associated with rapid drug distribution between the plasma and peripheral compartments and variation in lidocaine binding to plasma proteins. However, during constant lidocaine infusion, a steady-state concentration was achieved within 70 min, as demonstrated by the constant saliva/plasma concentration ratios.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parotid Gland
/
Saliva
/
Lidocaine
Limits:
Animals
Language:
En
Journal:
J Pharm Sci
Year:
1979
Document type:
Article