Urinary excretion of methylated purines in man and in the rat after the administration of theophylline.
J Chromatogr
; 163(4): 351-62, 1979 Aug 21.
Article
in En
| MEDLINE
| ID: mdl-583494
ABSTRACT
Chromatographic characteristics of urinary metabolites of theophylline were studied by two-dimensional thin-layer chromatography, high-performance liquid chromatography and gas chromatography--mass spectrometry. Quantitative date for the urinary metabolites of theophylline in asthmatic children are given. It was shown that 1,3-dimethyluric acid is the predominant excretory product. In addition, smaller amounts of 1-methyluric acid, 3-methylxanthine and unchanged theophylline were found. Excretory patterns after theophylline ingestion before and during the administration of allopurinol in asthma patients and in rats suggest the existence of three metabolic pathways of theophylline. The administration of this drug to a patient with xanthine oxidase of theophylline. The administration of this drug to a patient with xanthine oxidase deficiency resulted in the excretion of 1-methyluric acid in addition to 1,3-dimethyluric acid, 3-methylxanthine, 1-methylxanthine and unchanged theophylline. It was concluded that in man the oxidation of theophylline is not catalysed by xanthine oxidase.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Purines
/
Theophylline
Limits:
Animals
/
Child
/
Humans
/
Male
Language:
En
Journal:
J Chromatogr
Year:
1979
Document type:
Article