Methoprene and hydroprene are metabolized by ester cleavage in isolated hepatocytes.
Drug Metab Dispos
; 8(5): 309-12, 1980.
Article
in En
| MEDLINE
| ID: mdl-6107227
ABSTRACT
Methoprene (isopropyl [2E,4E]-11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate) and hydroprene (ethyl[2E,4E]-3,7,11-trimethyldodeca-2,4-dienoate) are actively metabolized, mainly to their corresponding acids by isolated rat hepatocytes and rat liver subcellular fractions. Small amounts of conjugates corresponding to glucuronides are also found. The esterase activity is of microsomal origin and is almost completely inhibited by tri-o-tolyl phosphate in isolated hepatocytes and microsomal fractions supplemented with NADPH. No evidence for the participation of the NADPH-dependent cytochrome P-450 system in the metabolism of either compound was observed.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Microsomes, Liver
/
Esterases
/
Fatty Acids, Unsaturated
/
Juvenile Hormones
/
Methoprene
Limits:
Animals
Language:
En
Journal:
Drug Metab Dispos
Journal subject:
FARMACOLOGIA
Year:
1980
Document type:
Article