Ontogeny of myocardial adrenoceptors II. Alpha adrenoceptors.
Pediatr Res
; 16(5): 340-2, 1982 May.
Article
in En
| MEDLINE
| ID: mdl-6124927
ABSTRACT
The maturation of myocardial alpha adrenoceptors was investigated in dogs. Alpha adrenoceptors were characterized by radioligand binding using [3H]-WB4101. In neonatal cardiac membranes, the binding of the ligand was rapid, reversible, of high affinity, saturable and stereoselective. The competition studies with adrenergic agonists and antagonists were indicative of alpha adrenoceptors. In adult dog cardiac membranes, consistent specific binding of the ligand could be demonstrated. These studies indicate that there is a decrease in alpha adrenergic receptor density of canine cardiac membranes during maturation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, Adrenergic
/
Receptors, Adrenergic, alpha
/
Myocardium
Limits:
Animals
Language:
En
Journal:
Pediatr Res
Year:
1982
Document type:
Article