Functional restoration of the traumatically injured spinal cord in cats by clonidine.
Science
; 217(4564): 1042-4, 1982 Sep 10.
Article
in En
| MEDLINE
| ID: mdl-6126002
ABSTRACT
The long-term, chronic, paralysis resulting from spinal cord injury in the cat has been reversed by the use of an alpha 2-adrenergic receptor agonist, clonidine. Administration of this drug resulted in "normalization" of sensory-motor and autonomic dysfunctions. Preliminary studies of the clonidine in humans with traumatically injured spinal cord indicate that autonomic dysreflexia can be controlled and spasticity minimized. The data suggest that biochemical and pharmacologic manipulation of receptors may ameliorate paralysis following traumatic injury to the spinal cord as well as to the brain and brainstem.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Spinal Cord Injuries
/
Receptors, Adrenergic
/
Receptors, Adrenergic, beta
/
Clonidine
Limits:
Animals
/
Humans
Language:
En
Journal:
Science
Year:
1982
Document type:
Article
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA