Vidarabine monophosphate and human leukocyte interferon in chronic hepatitis B infection.
JAMA
; 247(16): 2261-5, 1982 Apr 23.
Article
in En
| MEDLINE
| ID: mdl-6175774
ABSTRACT
Ten young adult patients with chronic hepatitis B virus infection and positive hepatitis B e antigen and DNA polymerase (DNAP) levels were treated with alternating courses of seven to 28 days of 5 to 7.5 mg/kg of vidarabine monophosphate (adenine arabinoside monophosphate) and 28 days of human leukocyte interferon (IFN-alpha); three different regimens were given on an outpatient basis. All patients with a fall in their DNAP level, and the DNAP remained undetectable six months after treatment was stopped in one patient. The major side effect, which most often occurred in those patients receiving 7.5 mg/kg of vidarabine monophosphate, was severe muscular pains. This study demonstrated the feasibility of administering vidarabine monophosphate and interferon to outpatients. Based on data from this and other studies, it is now possible to use a relatively nontoxic regimen that includes 28 days of 5 mg/kg of vidarabine monophosphate in a larger controlled study to answer the question of efficacy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vidarabine Phosphate
/
Arabinonucleotides
/
Interferons
/
Hepatitis B
Type of study:
Clinical_trials
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
JAMA
Year:
1982
Document type:
Article