Light-scattering studies on bile acid salts I: Pattern of self-association of sodium cholate, sodium glycocholate, and sodium taurocholate in aqueous electrolyte solutions.
J Pharm Sci
; 67(2): 174-81, 1978 Feb.
Article
in En
| MEDLINE
| ID: mdl-621632
ABSTRACT
The pattern of association of the trihydroxy bile salts in aqueous electrolyte solutions was investigated utilizing the light-scattering technique. The turbidity of the bile salts sodium cholate, sodium taurocholate, and sodium glycocholate was determined over the concentration range of 0-25 mg/ml at 25 degrees. For sodium cholate, the concentration of the supporting electrolyte was varied from 0.15 to 0.5 M. For all bile salts in 0.15 M electrolyte, the turbidity was determined in sodium fluoride, sodium chloride, sodium bromide, and sodium iodide. Comparison of the light-scattering data with amonomer-micellar model showed that qualitative agreement was obtained; however, quantitative agreement could not be achieved. Further examination of the data showed that the light-scattering results were in good agreement with a model that includes dimers, trimers, and a higher aggregate containing approximately eight monomeric units.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Taurocholic Acid
/
Cholic Acids
/
Glycocholic Acid
Type of study:
Qualitative_research
/
Risk_factors_studies
Language:
En
Journal:
J Pharm Sci
Year:
1978
Document type:
Article