Chronoeffectiveness of indomethacin in four patients suffering from an evolutive osteoarthritis of hip or knee.
Chronobiologia
; 10(3): 245-54, 1983.
Article
in En
| MEDLINE
| ID: mdl-6357659
ABSTRACT
During a 4-week span 4 patients suffering from an evolutive osteoarthritis ingested 3 pills/day at fixed clock hours 0800, 1200 and 2000. One of the weeks was devoted to a (placebo) control span. During the other weeks only one of the 3 ingested pills contained the daily dose of 50 mg indomethacin. This latter, when taken at 1200, had the maximum effect on self-rated pain (decrease of 60% of the 24-h mean, p less than 0.0005) and self-rated stiffness (decrease of 54% of M, p less than 0.005) as well as on mean oral temperature.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteoarthritis
/
Indomethacin
/
Hip Joint
/
Knee Joint
Type of study:
Clinical_trials
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Chronobiologia
Year:
1983
Document type:
Article