Cerebrospinal fluid antibiotic concentrations in ventricular shunt infections.
Childs Brain
; 4(2): 74-82, 1978.
Article
in En
| MEDLINE
| ID: mdl-639602
ABSTRACT
The concentration of antibiotic in cerebrospinal fluid was measured during treatment of seven children with infected ventricular shunts. Antibiotics were administered via the ventricular shunt or through an external ventricular drain. 53 CSF samples were obtained 7-19 h after antibiotic administration. Wide variation in cerebrospinal fluid antibiotic concentration occurred from patient to patient following either route of administration. For optimal management of shunt infections, we recommend periodic assessment of antibiotic concentration or activity in ventricular fluid and determination of the minimum inhibitory concentration of antibiotic required for each pathogen.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Surgical Wound Infection
/
Cerebrospinal Fluid Shunts
/
Anti-Bacterial Agents
Limits:
Child
/
Humans
Language:
En
Journal:
Childs Brain
Year:
1978
Document type:
Article