[The importance of increased prostaglandins and prostacyclin for the effect of oxyfedrin in isolated guinea pig heart preparations]. / Zur Bedeutung einer vermehrten Freisetzung von Prostaglandinen und Prostazyklin für die Wirksamkeit von Oxyfedrin an isolierten Herzpräparaten des Meerschweinchens.
Arzneimittelforschung
; 34(12): 1739-42, 1984.
Article
in De
| MEDLINE
| ID: mdl-6397198
ABSTRACT
In isolated perfused heart preparations of guinea pigs coronary dilating and positive inotropic doses of oxyfedrine induce a significant increase of the release of prostaglandin-like substances (PLS) and prostacyclin (PGI2). Indometacin as an inhibitor of prostaglandin biosynthesis (140 mumol/l) enhances after a 10 min lasting perfusion contraction force and coronary flow of the hearts but inhibits PGI2-formation. Under these conditions oxyfedrine loses its positive influence on inotropism, coronary flow and PGI2-efflux. Indometacin (140 mumol/l) also completely abolishes the increase of cardiac performance of isolated auricle preparations by oxyfedrine (50 mumol/l). These findings agree with former results and indicate an involvement of the PLS- and PGI2-biosynthesis in the antianginal efficacy of oxyfedrine.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxyfedrine
/
Propiophenones
/
Prostaglandins
/
Epoprostenol
/
Heart
Limits:
Animals
Language:
De
Journal:
Arzneimittelforschung
Year:
1984
Document type:
Article