1-Acyltriazoles as antiinflammatory agents.
J Med Chem
; 25(3): 331-3, 1982 Mar.
Article
in En
| MEDLINE
| ID: mdl-6461764
ABSTRACT
Certain 1-acyl-3-phenyl-5-alkyltriazoles were synthesized and evaluated for antiinflammatory activity using the mouse active Arthus (MAA) reaction as the test system. Modification of the acyl group, 4-phenyl substituent, and alkyl group led to the selection of the most active member of this series, 1-acetyl-3-(4-chlorophenyl)-5-methyl-1,2,4-triazole (3c), for further evaluation as a novel nonacidic antiinflammatory agent.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Triazoles
/
Anti-Inflammatory Agents
Limits:
Animals
Language:
En
Journal:
J Med Chem
Journal subject:
QUIMICA
Year:
1982
Document type:
Article