[Kidney function during radiosensitization with metronidazole]. / Funktsiia pochek pri radiosensibilizatsii metronidazolom.
Med Radiol (Mosk)
; 29(8): 16-20, 1984 Aug.
Article
in Ru
| MEDLINE
| ID: mdl-6472068
ABSTRACT
Renal function was studied in patients with laryngeal cancer during radiation therapy performed under the conditions of mean fractionation in the presence of metronidazole radiosensitization up to the summary focal dose of 20 Gy. As compared to the findings before treatment an increase in the level of residual nitrogen, urea, uric acid and a decreased amount of creatinine in the plasma were noted. Decreased clearance of the urea, elevated Ambard's urosecretory constant were observed. The nature of these shifts was preserved even after the termination of subsequent radiation therapy up to the summary focal dose of 32 Gy without using the radiosensitogen. There is a possibility of a direct toxic effect of metronidazole on the renal tissue regardless of the state of oxygenation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Laryngeal Neoplasms
/
Kidney
/
Metronidazole
Limits:
Humans
Language:
Ru
Journal:
Med Radiol (Mosk)
Year:
1984
Document type:
Article