Antagonism of apomorphine-induced cage climbing behaviour and methamphetamine stereotypy by fenfluramine in mice.
Indian J Physiol Pharmacol
; 28(4): 326-30, 1984.
Article
in En
| MEDLINE
| ID: mdl-6543532
ABSTRACT
Pretreatment with fenfluramine (5 and 10 mg/kg, ip) in doses which induced head twitches was found to antagonize apomorphine-induced cage climbing behaviour and methamphetamine stereotypy in mice. Since fenfluramine (5 and 10 mg/kg) did not induce catalepsy it indicates that fenfluramine lacks postsynaptic striatal and mesolimbic dopamine receptor blocking activity and it is possible that the fenfluramine-induced enhancement of central 5-hydroxytryptamine neuronal transmission may be responsible for its antagonistic effect on apomorphine-induced climbing behaviour and methamphetamine stereotypy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stereotyped Behavior
/
Apomorphine
/
Fenfluramine
/
Methamphetamine
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Indian J Physiol Pharmacol
Year:
1984
Document type:
Article