Enhancement of the stimulating effect of fructose-1.6-diphosphate on the metabolic energy balance of carbohydrate-deficient bovine lenses by additional supply with ADP.

Hockwin, O; Korte, I; Noll, E; Licht, W

Hockwin, O; Korte, I; Noll, E; Licht, W.

Ophthalmic Res ; 15(3): 168-71, 1983.

Article in En | MEDLINE | ID: mdl-6634052

ABSTRACT

ABSTRACT

The energy supply in carbohydrate-deficient bovine lenses was disturbed, as could be demonstrated by measuring the content of free adenine nucleotides. It could be regenerated in part by a 3-hour-incubation in TCM 199 in the presence of fructose-1.6-diphosphate (FDP). Additional supply of ADP enhanced the stimulating effect of FDP towards formation of ATP, providing sufficient receptor molecules for the activated rate of glycolysis and probably also for the citric acid cycle.

Subject(s)

Adenosine Diphosphate/pharmacology; Carbohydrate Metabolism; Energy Metabolism/drug effects; Fructosediphosphates/pharmacology; Hexosediphosphates/pharmacology; Lens, Crystalline/drug effects; Adenosine Triphosphate/metabolism; Animals; Cattle; Glycolysis/drug effects; Lactates/metabolism; Lactic Acid; Lens, Crystalline/metabolism; Pyruvates/metabolism; Pyruvic Acid

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Collection: 01-internacional Database: MEDLINE Main subject: Adenosine Diphosphate / Energy Metabolism / Carbohydrate Metabolism / Fructosediphosphates / Hexosediphosphates / Lens, Crystalline Limits: Animals Language: En Journal: Ophthalmic Res Year: 1983 Document type: Article

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