Synthesis of [1-14C]1,2-cyclohexanedione bis(4-diethylenoxythiosemicarbazone) and preliminary biodistribution studies of this potential antitumor agent.
Int J Appl Radiat Isot
; 34(11): 1501-4, 1983 Nov.
Article
in En
| MEDLINE
| ID: mdl-6642709
ABSTRACT
A new compound, [1-14C]1,2-cyclohexanedione-bis(4-diethylenoxythiosemicarbazone) was found to have significant antitumor activity (% T/C = 245) when tested against sarcoma-180 ascites tumor in mice and thus may be a potentially useful drug. The compound can be easily labeled with 14C by employing the straightforward synthetic procedures detailed in this article. Results of the synthesis and purification are presented. Preliminary biodistribution studies of the labeled compound in both normal and tumor bearing mice were performed. The compound, when administered i.p., is rapidly absorbed and localized into most tissues. Urinary and biliary excretion are its major routes of elimination. Based on these studies, continued evaluation is recommended.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thiosemicarbazones
/
Antineoplastic Agents
Limits:
Animals
Language:
En
Journal:
Int J Appl Radiat Isot
Year:
1983
Document type:
Article