Pharmacokinetics of the cytostatic drugs used in the CMF-regimen.
Anticancer Res
; 3(4): 269-71, 1983.
Article
in En
| MEDLINE
| ID: mdl-6688337
ABSTRACT
Forty-one clinical patients were studied on the first day of the first course of the CMF-regimen; administered by a fixed dosage scheme depending solely on body surface area of the patient in question. Parmacokinetic parameters were calculated for each drug the data were analysed in conformity with the usual pharmacokinetic models. The results indicate a large pharmacokinetic variability, especially for cyclophosphamide (C). The large variability in plasma concentrations of C is presumed to be substantially attributable to the drug formula used.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Antineoplastic Combined Chemotherapy Protocols
/
Methotrexate
/
Cyclophosphamide
/
Fluorouracil
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Anticancer Res
Year:
1983
Document type:
Article