Central-nervous-system toxoplasmosis in homosexual men and parenteral drug abusers.
Ann Intern Med
; 100(1): 36-42, 1984 Jan.
Article
in En
| MEDLINE
| ID: mdl-6691657
ABSTRACT
Central-nervous-system toxoplasmosis developed in 7 of 269 patients with the acquired immunodeficiency syndrome reported to the New York City Health Department through July 1982. Focal neurologic abnormalities, mass lesions on computed-tomographic brain scans, lymphocytic cerebrospinal fluid pleocytosis, and detectable IgG antibody to Toxoplasma gondii were common; but IgG titers of 11024 or more, IgM antibody to T. gondii, and positive open brain biopsies were uncommon. Serologic findings suggested that the disease resulted from recrudescent rather than primary infection. Four of five patients improved when treated with sulfonamides and pyrimethamine, but 2 had relapses. An aggressive diagnostic approach and sometimes even empiric therapy are warranted when central-nervous-system toxoplasmosis is suspected in a seropositive patient with the acquired immunodeficiency syndrome.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Diseases
/
Homosexuality
/
Toxoplasmosis
/
Acquired Immunodeficiency Syndrome
/
Substance-Related Disorders
Type of study:
Diagnostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Ann Intern Med
Year:
1984
Document type:
Article