Further investigations on the cytological effects of some contraceptives.

ABSTRACT

PIP: Anovlar induces a mitodepressive effect, producing abnormal prophases and a considerable number of micronuclei, i.e., Anovlar can produce major cytological abnormalities. Conversely, Lyndiol induces minor abnormalities leaving the process of mitosis to proceed almost normally. Microgynon 30 did not show any effect on any of the mitotic stages. The conclusion may offer an explanation for the contradictory results found in the literature of the cytological effect of oral contraceptives, although the major chemical constitution of all contraceptives used is the same, still there are minor differences in their chemical structure. These minor differences may be the deciding factor as to whether or not a contraceptive is harmful.