Long-term treatment of congestive heart failure with captopril.
Br J Clin Pharmacol
; 14 Suppl 2: 223S-229S, 1982.
Article
in En
| MEDLINE
| ID: mdl-6753904
ABSTRACT
1 The efficacy of the converting-enzyme inhibitor captopril in the management of severe congestive heart failure was assessed in 14 patients over 360-885 days by clinical evaluation, M-mode echocardiography, systolic time intervals, plasma renin activity, and plasma aldosterone. 2 As compared with baseline values, a significant reduction was observed in heart rate, mean arterial pressure, left ventricular end-diastolic and end-systolic diameters, left ventricular pre-ejection period, tension time index, body weight, and plasma aldosterone. Significant increases in left ventricular ejection time and fractional circumferential shortening (p less than 0.01) were also observed. 3 The functional and haemodynamic benefit provided by captopril was therefore sustained during long-term therapy without severe untoward effects or attenuation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Proline
/
Captopril
/
Heart Failure
Limits:
Adult
/
Aged
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Br J Clin Pharmacol
Year:
1982
Document type:
Article