Decreased insulin binding to erythrocytes in subjects with Klinefelter's syndrome.
J Clin Endocrinol Metab
; 53(3): 654-5, 1981 Sep.
Article
in En
| MEDLINE
| ID: mdl-6790562
ABSTRACT
Insulin binding to specific erythrocyte receptors was investigated in group of 25 subjects with Klinefelter's syndrome (47 XXY genotype) and 14 healthy male volunteers. Insulin binding was significantly decreased in Klinefelter subjects (P less than 0.01 at insulin concentrations of 0.051 and 0.136 mmol/liter); however, their fasting glucose concentration was normal (87 +/- 17), and the glucose disappearance rate was slightly increased (2.3 +/- 0.9; P less than 0.2). These data indicated a compensatory, mechanism involved in the glucose metabolism in Klinefelter's syndrome.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptor, Insulin
/
Erythrocyte Membrane
/
Erythrocytes
/
Insulin
/
Klinefelter Syndrome
Limits:
Humans
/
Male
Language:
En
Journal:
J Clin Endocrinol Metab
Year:
1981
Document type:
Article