Concerning the structure of photobilirubin II.
Biochem J
; 201(1): 179-88, 1982 Jan 01.
Article
in En
| MEDLINE
| ID: mdl-7082282
ABSTRACT
Evidence is presented which supports the postulate that the photobilirubins IIA and IIB are diastereoisomers in which the C-3 vinyl group has cyclized intramolecularly. The evidence comes principally from proton n.m.r. spectroscopy at 400 MHz and from chemical considerations. The cyclic structures require the E-configuration at the C-4 double bond in the precursor; this is the first structural evidence for the Z leads to E isomerization in bilirubin and supports the view that the precursor (photobilirubin IA or IB) is (4E, 15Z)-bilirubin. Brief irradiation of photobilirubin II gives bilirubin, a new compound (photobilirubin III) and unchanged starting material. The various photoisomers are discussed in terms of their inter-relationships and biological fates.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bilirubin
Language:
En
Journal:
Biochem J
Year:
1982
Document type:
Article