Hepatotoxicity of phenacetin and paracetamol in the Gunn rat.
Pathology
; 13(4): 757-62, 1981 Oct.
Article
in En
| MEDLINE
| ID: mdl-7335382
ABSTRACT
Both phenacetin and paracetamol produce acute centrilobular liver necrosis in the homozygous Gunn rat. Paracetamol is more hepatotoxic than phenacetin, and both are more hepatotoxic to the homozygous Gunn rat than to the heterozygous Gunn rat or to the albino rat. These findings have relevance to the role of the compounds in the clinical syndromes of paracetamol induced liver necrosis and analgesic nephropathy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenacetin
/
Liver
/
Acetaminophen
Limits:
Animals
Language:
En
Journal:
Pathology
Year:
1981
Document type:
Article