Distribution of 99mTc-phosphate compounds in osteoarthritic femoral heads.
J Bone Joint Surg Am
; 62(1): 90-6, 1980 Jan.
Article
in En
| MEDLINE
| ID: mdl-7351422
ABSTRACT
UNLABELLED In a study of the distribution of 99mTc-polyphosphate and 99mTc-methylene diphosphonate in osteoarthritic femoral heads by macroautoradiography of samples obtained during replacement surgery, the bone-seeking agents were seen to accumulate in the weight-bearing, denuded areas, mainly in the cyst walls and at the osteochondral junctions in the osteophytes. The autoradiographic findings were substantiated by findings from impulse-counting of different zones in the femoral heads that were done on frozen sections. Morphological studies of sections adjacent to the cut surface used for autoradiography showed that the accumulations of the radionuclides were located in areas of new-bone formation, particularly enchondral ossification. This finding was confirmed by histochemical staining for alkaline phosphatase, a marker enzyme for bone mineralization. The over-all distribution of alkaline phosphatase activity in cells roughly paralleled the deposition of the bone-seeking agents. CLINICAL RELEVANCE Scintigrams of osteoarthritic joints reflect primarily the rate of osteogenesis in subchondral bone and osteophytes. As the scan is positive even in very early stages in the development of the disease, a more detailed knowledge of the mechanism responsible for an increased uptake of 99mTc-phosphate compounds may, among other things, contribute to the elucidation of the pathogenesis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteoarthritis
/
Femur Head
Limits:
Humans
Language:
En
Journal:
J Bone Joint Surg Am
Year:
1980
Document type:
Article
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA