Synthesis and biological activity of 9-deoxo-9-methylene and related prostaglandins.
Adv Prostaglandin Thromboxane Res
; 6: 355-63, 1980.
Article
in En
| MEDLINE
| ID: mdl-7386275
ABSTRACT
A number of PGE analogs have been synthesized in which the C-9 carbonyl group has been replaced by an exo-methylene group. These chemically stable 9-deoxo-9-methylene-PGEs exhibit biological profiles very similar to their less stable PGE relatives. 9-Deoxo-16,16-dimethyl-9-methylene-PGE2 (7) retains the useful uterine-stimulating potency of 16,16-dimethyl-PGE2 but is approximately 300 times less enteropooling in the rat. In preliminary clinical trials, 7 has shown efficacy for pregnancy termination by the oral and vaginal routes of administration, as well as relative freedom from gastrointestinal side effects.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prostaglandins E, Synthetic
/
16,16-Dimethylprostaglandin E2
Limits:
Animals
Language:
En
Journal:
Adv Prostaglandin Thromboxane Res
Year:
1980
Document type:
Article