Glycosylated hemoglobins and their relation to the control of juvenile diabetes mellitus.
Helv Paediatr Acta
; 33(6): 535-42, 1978 Dec.
Article
in En
| MEDLINE
| ID: mdl-738904
ABSTRACT
Patients with juvenile diabetes mellitus were studied over a period of six months. During this time their metabolic control was classified and the relation between the blood concentration of the glycosylated hemoglobins Hb A1a + b + c and the degree of diabetic control was established. 12 out of 37 diabetic children were under good control, whereas 6 patients were poorly controlled. Well controlled children had low concentrations of glycosylated hemoglobins, within the range of non-diabetic subjects. Those under poor control showed an almost twofold increase of the concentration of these minor hemoglobins. Hb A1a + b + c levels of 8 newly diagnosed diabetics were also extremely elevated. Since the hemoglobin-sugar linkage is irreversible, these components remains much longer elevated than the blood glucose itself. It is concluded that the determination of Hb A1a + b + c levels is a valuable tool for the evaluation of the efficiency of diabetic therapy in addition to blood and urinary glucose measurements.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hemoglobin A
/
Diabetes Mellitus, Type 1
Limits:
Adolescent
/
Child
/
Humans
Language:
En
Journal:
Helv Paediatr Acta
Year:
1978
Document type:
Article