3'-Deoxy-3'-fluoroinosine as a potent antileishmanial agent. The metabolism and selective cytotoxic effect of 3'-deoxy-3'-fluoroinosine against Leishmania tropica and L. donovani in vitro and in vivo.

Shin, I S; Tanifuji, H; Arata, Y; Morizawa, Y; Nakayama, T; Wataya, Y

Shin, I S; Tanifuji, H; Arata, Y; Morizawa, Y; Nakayama, T; Wataya, Y.

Affiliation

Shin IS; Faculty of Pharmaceutical Sciences, Okayama University, Japan.

Parasitol Res ; 81(7): 622-6, 1995.

Article in En | MEDLINE | ID: mdl-7479655

Subject(s)

Antiprotozoal Agents/metabolism; Antiprotozoal Agents/toxicity; Inosine/analogs & derivatives; Leishmania donovani/drug effects; Leishmania tropica/drug effects; Leishmaniasis, Visceral/drug therapy; Animals; Antiprotozoal Agents/therapeutic use; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Inosine/metabolism; Inosine/therapeutic use; Inosine/toxicity; Leishmania donovani/growth & development; Leishmania tropica/growth & development; Male; Mice; Mice, Inbred BALB C; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Leishmania donovani / Leishmania tropica / Inosine / Leishmaniasis, Visceral / Antiprotozoal Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: Parasitol Res Journal subject: PARASITOLOGIA Year: 1995 Document type: Article Affiliation country: Japan

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