Different expression of the myotonin protein kinase gene in discrete areas of human brain.
Biochem Biophys Res Commun
; 216(2): 489-94, 1995 Nov 13.
Article
in En
| MEDLINE
| ID: mdl-7488138
ABSTRACT
We have examined the myotonin protein kinase (MT-PK) gene expression in different human brain areas. Four different spliced forms, comprising exons 13 and 14, were identified and characterized. One form (MYOT-A), lacking the entire exon 13, had not been detected in other studies and it is likely to be a brain-specific transcript. Different brain areas show a specific transcription pattern. These results suggest that MT-PK may have specialized functions in different areas of central nervous system. Alterations of this complex expression pattern could be responsible for the mental status impairment observed in myotonic dystrophy patients.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protein Kinases
/
Brain
/
Gene Expression
/
Protein Serine-Threonine Kinases
/
Alternative Splicing
Limits:
Humans
Language:
En
Journal:
Biochem Biophys Res Commun
Year:
1995
Document type:
Article
Affiliation country:
Italy