Characterization of des-(741-1668)-factor VIII, a single-chain factor VIII variant with a fusion site susceptible to proteolysis by thrombin and factor Xa.

Donath, M J; de Laaf, R T; Biessels, P T; Lenting, P J; van de Loo, J W; van Mourik, J A; Voorberg, J; Mertens, K

Donath, M J; de Laaf, R T; Biessels, P T; Lenting, P J; van de Loo, J W; van Mourik, J A; Voorberg, J; Mertens, K.

Affiliation

Donath MJ; Department of Blood Coagulation, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands.

Biochem J ; 312 ( Pt 1): 49-55, 1995 Nov 15.

Article in En | MEDLINE | ID: mdl-7492334

Subject(s)

Factor VIII/chemistry; Factor Xa/metabolism; Peptide Fragments/chemistry; Thrombin/metabolism; Animals; Factor IXa/metabolism; Factor VIII/isolation & purification; Factor VIII/metabolism; Factor VIII/pharmacokinetics; Guinea Pigs; Hemophilia A/metabolism; Humans; Kinetics; Peptide Fragments/genetics; Peptide Fragments/isolation & purification; Peptide Fragments/metabolism; Recombinant Fusion Proteins/chemistry; Recombinant Fusion Proteins/isolation & purification; Recombinant Fusion Proteins/metabolism; Recombinant Fusion Proteins/pharmacokinetics; Sequence Deletion/genetics; von Willebrand Factor/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Factor VIII / Thrombin / Factor Xa Limits: Animals / Humans Language: En Journal: Biochem J Year: 1995 Document type: Article Affiliation country: Netherlands Country of publication: United kingdom

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