2-Chloro-2'-deoxyadenosine (2-CdA) combined with cyclosporine A successfully prevents rejection of fetal brain stem allograft in rabbits.
Arch Immunol Ther Exp (Warsz)
; 42(1): 43-6, 1994.
Article
in En
| MEDLINE
| ID: mdl-7503634
ABSTRACT
Allografts of brain stem from 20-day-old fetuses to nucleus caudatus of adult rabbits were performed. To prevent graft rejection immunosuppression with 2-CdA and cyclosporine A was transiently induced. Graft survival were assessed by histological and electrophysiological techniques. Both morphological (synaptogenesis, myelinization) and functional (generation of rhythmic neuronal activity) signs of graft maturation were found after nine weeks. The data suggest that transient immunosuppression used is sufficient to induce tolerance to neural graft, and no interference with maturation of implanted fetal tissue occurs.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Stem
/
Brain Tissue Transplantation
/
Fetal Tissue Transplantation
/
Cyclosporine
/
Cladribine
/
Graft Rejection
/
Immunosuppressive Agents
Limits:
Animals
/
Pregnancy
Language:
En
Journal:
Arch Immunol Ther Exp (Warsz)
Year:
1994
Document type:
Article