Detection of hepatitis B virus DNA by polymerase chain reaction in vaccinated and non-vaccinated Senegalese children.
Arch Virol Suppl
; 8: 123-31, 1993.
Article
in En
| MEDLINE
| ID: mdl-7505143
ABSTRACT
An hepatitis B immunization programme was initiated in Senegal in 1978, and infants included in this controlled study have been followed for a period of 2-12 years after immunization. During this period HBV infections have been observed both in vaccinated and non-vaccinated infants. The polymerase chain reaction was used to search for HBV DNA sequences in the sera of 153 children with evidence of serum markers of past or present HBV replication. Amplified HBV DNA sequences were detected in 93% of the HBsAg positive individuals, in 58% of those only positive for antiHBc antibodies and in 7.8% of antiHBs and antiHBc positive infants. The results confirm the high efficiency and long-lasting effectiveness of HB vaccine.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
DNA, Viral
/
Hepatitis B virus
/
Polymerase Chain Reaction
/
Hepatitis B Vaccines
/
Hepatitis B
Type of study:
Clinical_trials
/
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limits:
Child, preschool
/
Humans
/
Infant
Country/Region as subject:
Africa
Language:
En
Journal:
Arch Virol Suppl
Journal subject:
VIROLOGIA
Year:
1993
Document type:
Article
Affiliation country:
France