Cell Adhesion Molecules/analysis; Cell Adhesion Molecules/physiology; Cytokines/analysis; Cytokines/physiology; Scleroderma, Systemic/metabolism; Scleroderma, Systemic/physiopathology; Skin/chemistry; Skin/physiopathology; Adult; Aged; Biopsy; Carrier Proteins/analysis; Carrier Proteins/metabolism; Carrier Proteins/physiology; Cell Adhesion/physiology; Cell Adhesion Molecules/metabolism; Cytokines/metabolism; Endothelium/metabolism; Endothelium/pathology; Endothelium/physiology; Female; Fibroblasts/metabolism; Fibroblasts/pathology; Fibroblasts/physiology; Humans; Hyaluronan Receptors; Immunohistochemistry; Interleukin-6/analysis; Interleukin-6/metabolism; Interleukin-6/physiology; Interleukin-8/analysis; Interleukin-8/metabolism; Interleukin-8/physiology; Male; Middle Aged; P-Selectin; Platelet Membrane Glycoproteins/analysis; Platelet Membrane Glycoproteins/metabolism; Platelet Membrane Glycoproteins/physiology; Receptors, Cell Surface/analysis; Receptors, Cell Surface/metabolism; Receptors, Cell Surface/physiology; Receptors, Lymphocyte Homing/analysis; Receptors, Lymphocyte Homing/metabolism; Receptors, Lymphocyte Homing/physiology; Scleroderma, Systemic/pathology; Skin/pathology; Tumor Necrosis Factor-alpha/analysis; Tumor Necrosis Factor-alpha/metabolism; Tumor Necrosis Factor-alpha/physiology; Vascular Cell Adhesion Molecule-1