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Dual mode of signal transduction by externally added acidic fibroblast growth factor.
Wiedlocha, A; Falnes, P O; Madshus, I H; Sandvig, K; Olsnes, S.
Affiliation
  • Wiedlocha A; Institute for Cancer Research, Norwegian Radium Hospital, Montebello, Oslo.
Cell ; 76(6): 1039-51, 1994 Mar 25.
Article in En | MEDLINE | ID: mdl-7511061
Acidic fibroblast growth factor (aFGF), fused to diphtheria toxin and translocated into cells, stimulated DNA synthesis in toxin-resistant cells lacking functional aFGF receptors while having a high number of diphtheria toxin receptors. In NIH 3T3 cells that lack diphtheria toxin receptors, but have receptors for aFGF, both aFGF and the fusion protein induced tyrosine phosphorylation, but only aFGF as such entered the nuclei and stimulated DNA synthesis. The results indicate that signaling occurs partly through cell surface receptors and partly by transport of the growth factor into the cell.
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Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Fibroblast Growth Factor 1 Limits: Animals / Humans Language: En Journal: Cell Year: 1994 Document type: Article Country of publication: United States
Search on Google
Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Fibroblast Growth Factor 1 Limits: Animals / Humans Language: En Journal: Cell Year: 1994 Document type: Article Country of publication: United States